Type: Process Essays
Sample donated: Christian Cohen
Last updated: September 21, 2019
FlavanoidsIntroduction:Oneof the largest nutrient family is Flavonoids which is known to researchers. Thisclass incorporate more than 6,000 officially distinguished flavonoids compounds.
A portion of the well-known flavonoids are quercetin, kaempferol, catechins,and anthocyanidins. This class is popular because of its cell reinforcement andmedical advantages and its piece of shading which offer it to the food nourishmentswhich we eat. Due to the famous fragile gathering of supplements as for cookinghearths, flavonoids are regularly front focus on our cooking strategies at Foods, where we search for cookingtechniques best ready to store theses flavonoids . Flavonoids are a well- knownclass of phytonutrients which incorporate into chemical class of polyphenols. 1They are most well known for their rich decent variety of shading, givingcolors (counting the deep blues of blueberries and rich reds of raspberries).The name of these phytonutrients is essentially came from their colour chemistry science, with the Latin word flavorssignifying “yellow.” As a group, in any case, flavonoids are veryproactive and play a fundamental contribution wide in the strength of plants,creatures, and human health .Untill , nowmore than 6,000 exceptional flavonoids have been recognized by the scientistsand a large number of these flavonoids are found in plants that are routinelydelighted in delicious cooking styles all through the world .
We get a greater numberof flavonoids from plants than from animals . Thus plants are the real sourceof flavonoids particularly vegetables and natural products are supplement richin this sort of phytonutrient. 2Someof the most generally considered flavonoids are supplements about you haveheard for example, the flavonoid quercetin. Different flavonoids you may havefound out about because of their relationship with a specific food,for example,the catechins in green tea. Now and then a flavonoid is anything but difficultto connect with its most supplement full substance sources, e.g, the tangeretin found in tangerines (andadditionally different citrus fruits).
Flavonoids are essential because oftheir cell reinforcement and medical advantages and the part in the support ofthe cardiovascular and sensory systemChemicaland Physical properties of Flavanoids:Thechemical nature of flavonoids depends on their structural class, degree ofhydroxylation, other substitutions and conjugations, and degree ofpolymerization. They vary in the structure around the heterocyclic oxygen ring,but all have the particular C6 —-C3 —-C6 carbon skeleton. So we can say all are derivatives of the 2- phenylchromoneparent compound composed of three phenolic rings referred to as A, B, and Crings that shows different levels of hydroxylation and methoxylation.3The biochemical activities of flavonoids and their metabolites depend on theirchemical structure and the relative orientation of various moieties in themolecule. Natural Sources ofFlavanouds:Flavonoidsare more common found in plants which are the major sources of flavanoids andplant derived are our largest mean of these health-supporting phytonutrients.All food which come from the plant, include flavanoids fruits and vegetables thatare more concernerd and most used for their flavonoid source.3 Flavonoid data is also present on nuts andseeds, grains, beans and legumes, and other foods and beverages (for example,green and black tea).It is necessary to remind that flavonoids are a verylargest group of phytonutrients.
Flavonoids are a major coloring component of flowering plants, which are foundin all plant foods. Flavonoids in food are mostly responsible for colour,taste, prevention of fat oxidation, and protection of vitamins and enzymes.4The five subcategories ofFlavanoids:5 a) Flavonols(include Quercetin , Kaempfero , myricetin and isorhamnetin )b) Flavan-3-ols (include Catechins , epicatechin, gallocatechin and theaflavins)c) Flavones( include Apigenin and luteolin )d) Flavanones( include Hasperetin , naringenin and eriodictyol )e) Anthocyanidins( include Cyanidin , Delphinidin , Malvidin , pelargondin , peonidin andpetundin )Foods Containing Flavonoids:The biggest and single mean of flavonoids isdark and green tea which are all the more usually utilized and 1/2 of allflavonoid take-up come from the Flavan-3-ol subgroup which is full in tea. Thissubgroup incorporates catechins, epicatechins, gallocatechins, and theaflavins5.In the anthocyanidin coulumn , the bright red, blues , and the purples in berries are the fruits determined by anthocyanidinand found the place in this column .6FruitjuicesFruitsare the daily uptake diet of humans.Fruits are the major source of flavonoids.
Fruitjuices made from raw, unprocessed fruit . Red wine made from the grapes andgrape juice containing high level of anthocyanidins and the flavonols quercetinand myricetin. Black, red and green varieties of tea are rich of catechins suchas epigallocatechin along with related flavonols such as thearubigin.7 SPICESSpicesare the major part of human food. Spices are daily used in food.
NO food is suchin which spices are not used.Spices are full of flavonoids. They are used inless quantite , offer some health benefits especially if used when they arefresh. Dill is known to be rich in the flavonols quercetin and isorhamnetinwhile parsley is rich in apigenin along with isorhamnetin. Thyme is also richin the flavones luteolin and capers but used routinely, very rich in theflavonols kaempferol andquercetin. People should also known that chocolate isvery high in catechins, particularly if used in the dark variety. BERRIES:Alarge quantity of the berries is rich in flavonoids, especially red, blue andpurple berries.
Dark and riper berries considererd to have high flavonoidcontent.But their processing may low down their levels. Blueberries andcranberries are considererd to contain amount of the flavonol group whichinclude quercetin and myricetin.
Blackberries and black grapes are high in theflavonoids epicatechin and catechin while raspberries, cherries and red grapes containanthocyanidins and cyanidin.FRUITS:Amajor source of flavonoids is the fruits that grow on the trees.Bananas haveamount of anthocyanidins containing cyanidin and delphinidin. Citrus fruitswhich include grapefruit, lemons, limes and oranges are those which have highcontent in the flavonone group of flavonoids including hesperetin, naringeninand eriodictyol.Many Members of Rosaceae family including apples, pears, plums,peaches and apricots rich in catechin and epicatechin.They are best if consumedwith skin on.8 VEGETABLES:Manyvegetables are also the source of flavonoids.many has quantities of flavonoidsespecially green and red vegetables.
Members of the nightshade family whichinclude peppers, tomatoes and eggplants are rich in the flavonols, quercetinand the flavones luteolin. Onions especially, red onions and green onions arealso rich in quercetin. Green vegetables like celery and artichokes are rich inthe flavones apigenin and luteolin.Vegetables such as snap beans, okra andbroccoli are high in flavonols including quercetin, kaempferol and myricetin.
9 Riskof Dietary Deficiency:Themost of flavonoids which we uptake came from the black and green tea which aremostly used in the household and the major consumption is from these. From theheaith point of view , The real utilization with dark and green tea which fill in as meanof the phytonutrients. We arrange level of uptake to be lacking from awellbeing point of view. We don’t have any great standard to decide the idealflavonoid sums. In the nutrients , about the Flavanoids , there is no DietrayReference Intake (DRI) and no Daily Value (DV) .
Any person who consumes six vegetablesplus 4 fruits. 10 Anoteworthy measure of flavonoids is from a solitary flavonoid subgroup(flavan-3-ols gave from dark and green tea).So flavonoid insufficiency is fromalternate subgroups which give information about flavonoid utilization . Deficiencyis shown from the large intake of foods , overcooking of food , and the low consumption of fruits and vegetables. Natural foods which include fresh, brightly colored vegetables and fruitswhose flavonoid pigments provide them bright colors. This is simple method tomaximize your flavonoid intake. 11Relationof Flavanoids with Other Nutrients:Flavanoidshave connection with other nutrients.There is a nearby connection amongstflavonoids and vitamin C.
Flavonoids have part in the course of vitamin Caround the body and direct the capacity of a chemical called ascorbate oxidasethat change vitamin C into a non-vitamin frame (monodehydroascorbate). we don’thave finish data about these connections. The extraordinary nature of theserelationship empower us to make sense that most of the nutrients are rich inVitamin C and Flavanoids . e.
g. Papaya , bell peppers , broccoli , BrusselSprous and Strawberries . RoleOF Flavanoids in health of Humans:1:Flavanoids asAntioxidant:Manyof the flavonoids especially belonging to Flavonols and Flavan-3-ols areimportant in lessening free radical harm to cells and different parts in bodytissue .
They act as antioxidant reagent and have the antioxidant effect. Thebest known antioxidant are vitamin C or vitamin E.Theyact as like because their concentration is low in blood stream of human.Flavanoidsitself are not antioxidant but by metabolic activities they are converyed toantioxidant reagents. Blueberries has excellent role as antioxidant .12,13 2: :Flavanoids as Anti-Inflammatory :Flavanoidsact anti-inflammatory agents that keepthe informing atoms to be shaped that cause inflammation. Inhibition of cyclooxygenase (COX) and Lipoxygenase (LOX) enzymes are the action performed by flavonoids.
Many Flavanoids that came from the spices and herbs provide thes benefits..143:CardiovascularSystem Benefits:Flavanoidsare important as they have the major role in cardiovascular system ofhuman.many diseases of the cardiovascular system like stress and inflammation,the antioxidant and anti-inflammatory flavonoids help directly in solving theseproblem.Flavanoid help to protect LDL cholesterol level in the blood streams ofhumans from oxygen damage. LDL level lower the risk of atherosclerosis.Flavonoids such as rutin and hesperidin enhance the strength and protection ofwall the blood vessel .
So they solve the problems of blood vessel walls.TheFlavanoids which came from the orange , black pepper , rosemary , garlic ,ginger , they have the important role in vascular function .In addition to theherbs and spices herbs and spices the soy foods, chocolate, pomegranate juice, and grapejuice etc. also have the same function.
ManyFlavonoids like Quercetin and Rutinprevent stops clumping together of platelet and the blood vessels are cloggedby them .This activity of Flavonoids iscalled an “anti-aggregatory” activity.154:Rolein the nervous system:Flavanoidshelp in the nervous system to work best. They ensure the nerve cells which arefundamental unit of nervoys system . Out side the brain and spinal cord , theflavonoids intake has the slow and demanding process of the nerve regeneration.It is observed that the nervous diseases like Dementia and Alzheimer’s can beretarded by the long uptake of Flavanoids.
Better functioning of the brain andthe spinal cord like cognitive function is due to the flavonoids which increasethe rate of blood flow.5:Rolein the cancer:· Flavanoids have role in some otherdiseases. They have the the anticancer effect.· Because of their cancer prevention agentand mitigating properties, flavonoids are considered to bring down the dangerof specific growths, for example, endless oxidative pressure and endlessundesirable aggravation that can cause the cells of becoming cancerous .
166:Rolein the detoxification: Flavonoids modify the body’s detoxificationpathways , The toxins which are supposed to cause cancer are low exposed by theFlavanoids because they cancerous. Enhanced detoxificationis an advantage that we accomplish from solid flavonoid consumption like withthe zone of growth hazard. Undesirable contaminants are modified by our body. Two key steps associated with the procedure. a) In the initial step (called Phase 1),conceivably harming atoms are made more responsive with the goal that they canbe passed on to Phase 2. b) In the second, Phase 2 stage, theactivated molecules coordinate with neutralizing molecule and they become neutral. Flavonoidshave important part in both the means, detoxification ,in Phase 2, they improveconsolidating objective of Phase 2. But regarding to Phase 1, the part offlavonoids is much unpredictable in light of the fact that they can switchPhase 1 either on or off.
In any case, they can encourage and obstruct thisinitial phase in detoxification. This convoluted connection amongst flavonoidsand detoxification has appeared to bring down the danger of undesirable poison 17 7:Regulation of cell cycle:Flavanoidshave important role in circulation of cell cycles.Most of Cells pass throughstages of activity in which they rest, divide, self-recycling process calledapoptosis in our body.Flavanoids help to regulate the cell cycle in the body ofhumans.A sufficient amount of flavonoids intake promote the cell cycle to stayin balance and in regulation.18Riskof Dietary Toxicity:Dietrayflavanoids that found in the greenvegetables and nuts, legumes , beans , and whole grain are considered to betoxic sometime. They can be toxic if they are intake above the safe level .
buta sufficient amount is considered to be safe and they have no side effects.Most of the flavonoids are water soluble and they follow the same pattern ofthe water soluble dietary contents. So care is taken about the flavonoidsintake.PublicHealth Awareness:Peoplehave no awareness about the flavonoid intake.They do not know in how manyamount they are used.People have no awareness about the intake of Flavanoids quantity. They not known howmuch quantity is needed once a day. This is very serious issue which should beunderstand.
But there is no daily value (DV) From the National Academy ofScience. So there should be quite balance about the intake. So the balanceddiet must be used. ISOFLAVANOIDSIntroductionIsoflavonesare polyphenolic compounds that have properties related to estrogen-agonist andestrogen-antagonist . That is why they are classified as phytoestrogens (plant-derived compounds with estrogenic activity ). They are the mainflavonoids found in legumes, particularly soybeans. In soybeans, isoflavones boundto a sugar molecule and present in the glycoside.
19 Isoflavone glycoside on digestion or fermentationof soy products yield the sugar molecules, leaving behind an isoflavoneaglycone. Soy isoflavone glycosides which include genistin, daidzin, andglycitin while the Anglicans are called genistein, daidzein, and glycitein.20Food Sources:Isofavonesare found in the plants .The major source of isoflavones is the plants.
They arefound in the less quantity in a number of legumes, grains, and vegetables, butsoybeans are the major source of isoflavones in the human diet.Human beingintakes 25 to 50 mg/day daily dietry flavones. Dietary isoflavone intakes arerelatively lower in Western countries.
The popular Soy products are soy based meat substitutes such as soymilk, soy cheese, and soy yogurt.So the soy beans are the chief sources ofisoflavanoids which are intake by the human being from green plantsHealthBenefits of IsoFlavanoids:1:CancerPrevention:Isoflavanoidshave important role in treatment of cancer chemotherapy. Lung , breast and oralcancer are protected by the isoflavanoids rich food.
One of example is the Puerarin , rich in theflavonoids which has the effective role against colon cancer by the process ofapoptosis.21Safetyfor breast cancer survivorsSoyisoflavones have the important and good role in the breast cancer. People whohave the breast cancer showed that soy isoflavones excite the growth ofestrogen receptor positive (ER+) breast cancer cells but some shows that theymight either potentiate or rescind the anticancer effects of tamoxifen onbreast tissue .
22Theresearch from the clinical trials shows that increased intake of soyisoflavones (3to 45 mg/day) have the weak estrogenic effects in human breasttissue .But , a study in women with biopsy confirmed breast cancer found thatsupplementation with 200 mg/day of soy isoflavones did not increase breast cellproliferation , a marker of breast cancer risk ,over the two to six weeksbefore surgery when compared to a control group that did not take soyisoflavones . so we can say that the isoflanones have important role in thebreast cancer.2:Malereproductive health:Isoflavoneshave the negative effects on male reproductive system, which include thefeminization, erectile dysfunction, and infertility are primarily based onanimal studies and case reports . Exposure to isoflavones have no effect on theenhancement of sperm and semen. 3: Pregnancy The effect of an isoflavone rich diet on fetaldevelopment or pregnancy results in humans, and the safety of isoflavonesupplements during pregnancy has not been established. They may enhance orinhibit the level of estrogen production. They can also reduce the excessestrogen production.
23 4:Thyroidfunctionsoyisoflavone decrease the funtion of thyroid peroxidase, an enzyme which isnecessary for thyroid hormone synthesis . But the large amount of intakes ofsoy isoflavones do not show increase the risk of hypothyroidism as long asdietary iodine consumption is suitable .5:Cardiovascular DiseaseSomeisoflavanoids like genistein and diazein lower the rate of the chronic diseasesincluding chronic artery disease is linked with the uptake of soy containingfoods.
Atherosclerosis is prevented by the use of the isoflavanoids .24 6:As an AntioxidantIsoflavanoidsact as the antioxidant. Genistein inhibits the ultraviolet induced skin tumor.It also reduce the H2O2 Production and facilitate theantioxidant property of the enzymes like catalase ,Superoxide dismutase ,glutathione reductase . So , pure isoflavanoids extracted from the plants areconsidered to be antioxidant.257:Metabolic ActivitySafety:Soyisoflavones are consumed by humans as part of the soy-based diets for manyyears without knowledge of the side effects.
Diets containing soy or soy-containing products are safe andactually useful but the long term intake of these food is not yet known. Anexperiment in older men and women shows that 100 mg/day of soy isoflavones tillsix months along with tolerated longer-term studies are needed to assess the safety of isoflavone. ConclusionSo, Flavanoids and iso flavonoids are very important because they have manyfunction in the human life. They are easily available from the plant sources ,that is why they are cheap and easily accessible. They have the role in varioushuman diseases which are decreased by the consumption of these.
But excessamount has the risk of negative effects. So, they find important place in fieldof science. References 1. Harborne, J. B.
, Turner, B. L., & Harborne,J. B. (1984). Plant chemosystematics (Vol. 123). London:Academic Press.
2. Yao, L. H.
, Jiang, Y. M., Shi, J.,Tomas-Barberan, F. A., Datta, N., Singanusong, R.
, & Chen, S. S. (2004).Flavonoids in food and their health benefits. Plant foods for humannutrition, 59(3), 113-122.3.
Cook, N. C., & Samman, S. (1996).Flavonoids—chemistry, metabolism, cardioprotective effects, and dietarysources. The Journal of nutritional biochemistry, 7(2),66-76.4.
Brodowska, K. M. (2017). Natural flavonoids:classification, potential role, and application of flavonoid analogues. EuropeanJournal of Biological Research, 7(2), 108-123.
5. Erlund, I. (2004). Review of the flavonoidsquercetin, hesperetin, and naringenin. Dietary sources, bioactivities,bioavailability, and epidemiology. Nutrition Research, 24(10),851-874.6. de Pascual-Teresa, S.
, & Sanchez-Ballesta,M. T. (2008). Anthocyanins: from plant to health. Phytochemistryreviews, 7(2), 281-299.7. Yamanishi, T.
(1995). Special issue on tea:Flavor of tea. Food Review Int., 11, 477-525.8. Gil-Izquierdo, A., Gil, M.
I., Ferreres, F.,& Tomás-Barberán, F. A. (2001). In vitro availability of flavonoids andother phenolics in orange juice.
Journal of Agricultural and FoodChemistry, 49(2), 1035-1041.9. Macready, A. L., George, T. W.
, Chong, M. F.,Alimbetov, D. S., Jin, Y., Vidal, A., ..
. & Gordon, M. H. (2014).Flavonoid-rich fruit and vegetables .The American journal of clinicalnutrition, 99(3), 479-489.10.
Arts, I. C., van de Putte, B., & Hollman,P. C.
(2000). Catechin contents of foods commonly consumed in The Netherlands.1. Fruits, vegetables, staple foods, and processed foods. Journal ofagricultural and food chemistry, 48(5), 1746-1751.
11. Tomás?Barberán, F. A.
, & Clifford, M. N. (2000). Flavanones, chalcones anddihydrochalcones–nature, occurrence and dietary burden.
Journal of theScience of Food and Agriculture, 80(7), 1073-1080.12. Kagan, V. E.
, Nohl, H., Quinn, P. J., Cadenas,E., & Packer, L. (1996).
Handbook of Antioxidants.13. Pannala, A. S., Chan, T. S.
, O’Brien, P. J.,& Rice-Evans, C. A.
(2001). Flavonoid B-ring chemistry and antioxidantactivity: fast reaction kinetics. Biochemical and Biophysical ResearchCommunications, 282(5), 1161-1168.14. Middleton Jr, E., & Kandaswami, C. (1992).Effects of flavonoids on immune and inflammatory cell functions.
Biochemicalpharmacology, 43(6), 1167-1179.15. Tijburg, L. B.
M., Mattern, T., Folts, J.
D.,Weisgerber, U. M., & Katan, M.
B. (1997). Tea flavonoids and cardiovasculardiseases: a review. Critical Reviews in Food Science & Nutrition, 37(8),771-785.16. Hertog, M.
G., Hollman, P. C.
, & Katan, M.B. (1992). Content of potentially anticarcinogenic flavonoids of 28 vegetablesand 9 fruits commonly consumed in the Netherlands.
Journal ofagricultural and food chemistry, 40(12), 2379-2383.17. Walle, T. (2004). Absorption and metabolism offlavonoids. Free Radical Biology and Medicine, 36(7),829-837.
18. Hertog, M. G., Hollman, P. C., & Katan, M.B.
(1992). Content of potentially anticarcinogenic flavonoids of 28 vegetablesand 9 fruits commonly consumed in the Netherlands. Journal ofagricultural and food chemistry, 40(12), 2379-2383.
19. Du, H., Huang, Y., & Tang, Y.
(2010).Genetic and metabolic engineering of isoflavonoid biosynthesis. Appliedmicrobiology and biotechnology, 86(5), 1293-1312.20. Jaganath, I. B., & Crozier, A. (2010).
Dietary flavonoids and phenolic compounds. Plant phenolics and humanhealth: biochemistry, nutrition, and pharmacology, 1, 1-50.21. Watanabe, S.
, Uesugi, S., & Kikuchi, Y.(2002). Isoflavones for prevention of cancer, cardiovascular diseases,gynecological problems and possible immune potentiation. Biomedicine& pharmacotherapy, 56(6), 302-312.22. Sarkar, F.
H., & Li, Y. (2003). Soyisoflavones and cancer prevention: Clinical science review.
Cancerinvestigation, 21(5), 744-757.23. Cederroth, C. R., & Nef, S.
(2009). Soy,phytoestrogens and metabolism: A review. Molecular and cellularendocrinology, 304(1-2), 30-42.24. Lissin, L.
W., & Cooke, J. P. (2000).Phytoestrogens and cardiovascular health.
Journal of the AmericanCollege of Cardiology, 35(6), 1403-1410.25. Wei, H.
, Zhang, X., Wang, Y., & Lebwohl, M.
(2002). Inhibition of ultraviolet light-induced oxidative events in the skinand internal organs of hairless mice by isoflavone genistein. Cancerletters, 185(1), 21-29.