Type: Process Essays
Sample donated: Franklin Dunn
Last updated: August 13, 2019
From Greek means “eating of self,” autophagy is a process that leadsto the destruction of particular importance in stressful situations such asstarvation . The regulation and implementation of life anddeath intention require advanced cellular pathways that can accommodate manyintrinsic and extrinsic factors, including metabolic and hormonal signals,nutritional state and absorption, and abiotic and biotic stresses . Now evidence shows that autophagy acts as a mechanismfor targeting a wide range of additional or toxic components in controllingcellular quality and stress response . It has now been proven that autophagy mechanisms contribute to theabundance of plant life cycle processes including reproduction, development,primary metabolism, signaling hormone, cellular homeostasis, senescence, stressresponse and disease resistance . Autophagy is an intracellulartrafficking and destruction pathway, with key activities protected fromcellular poisoning, development, and stress responses from yeast to plants andmammals.
Autophagic mechanisms relies on two membrane-specific vesicles called autophagosomes, which transfer cytoplasmic portions to lytic portions to remove unwanted substances, or generate energy blocks andbuilding blocks. Autophagosome formed in the structure preautophagosomal /phagophore assembly site (PAS) begins and expansion Phagophore around cellular targets . The outer membrane of autophagosome becomescomplete and finally fuseswith the vacuole (in yeast and plants) or lysosome (in mammals) to release theautophagic body to destroy the hydrolytic cargo.
The successive stages of Autophagy’s relianceon extensive membrane remodeling and trafficking events and requirethe concerted action of more than 30 ATG-dependent genes. first identified by extensive genetic displays in yeast, most of the ATGproteins has orthologs in higher eukaryotesand are highly protective core autophagymachinery.